Dr James R. Bentham

Consultant Paediatiatric Cardiologist

Area of Expertise

Interventional Paediatric and Adult congenital cardiology
Management and improving outcomes for high risk infants with complex congenital heart disease


Medical training at University of Oxford from 1993-1999 (1st class degree in physiological sciences, MA BM BCh)
Paediatric Training at John Radcliffe Hospital Oxford followed by Alder Hey Children’s Hospital (2000-2005)
PhD in molecular mechanisms in congenital heart disease at University of Oxford (2005-2008, DPhil)
Paediatric Cardiology training at John Radcliffe Hospital, Oxford and Great Ormond Street Hospital, London (2008-2011)
Interventional Cardiology training at Leeds General Infirmary (2011-2013)
Senior Intervention post CCT fellowship at Harvard Medical School, Boston Children’s Hospital, USA (2013-2014)

Specialist Interests

Interventional cardiology in adults and children
Research into interventional cardiology procedures and outcomes

See Publications

2016 Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. Sifrim A et al. Nature Genetics 2016; 48: 1060-1065.
2016 Exome sequencing identifies rare variants in multiple genes in atrioventricular septal defect. D’Alessandro LC et al. Genet Med. 2016 Feb;18(2):189-98.
2015 A reinforced right-ventricle-to-pulmonary-artery conduit for the stage-1 Norwood procedure improves pulmonary artery growth. Bentham JR, Baird CW, Porras DP, Rathod RH & Marshall AC. J Thorac Cardiovasc Surg. 2015 Jun;149(6):1502-8.
2015 Current state of interventional cardiology in congenital heart disease. Bentham JR & Thomson JD. Arch Dis Child. 2015 Aug;100(8):787-92.
2015 Patent ductus arteriosus: background and indications for closure. Bentham J and Wilson N. Structural, Valvular and Congenital Heart Disease Interventions, second edition. Eds Sievert Qureshi Wilson Hijazi. Informa Healthcare.
2015 Targeted Next-Generation Sequencing analysis of 1000 Individuals with Intellectual Disability. Grozeva et al. Human Mutation 2015; 36: 1197-1204.
2015 Ultrasound guided vascular access. Bentham J and Wilson N. Structural, Valvular and Congenital Heart Disease Interventions, second edition. Eds Sievert Qureshi Wilson Hijazi. Informa Healthcare.
2014 Rare variants in NR2F2 cause congenital heart defects in humans. Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D’Alessandro LC, Swaminathan GJ, Bentham J et al. Am J Hum Genet. 2014; 94: 574-585.
2013 Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Bentham J, Cordell H et al. Nature Genetics. 2013; 45: 822-824.
2013 Transcatheter and endovascular stent graft management of coarctation-related pseudoaneurysms. Khavandi A, Bentham J, Marlais M et al. Heart 2013; 17: 1275-1281.
2013 Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7,697 cases and 13,125 controls. Mamasoula C, Prentice R, Pierscionek T, Pangilinan F, Mills J, Druschel C, Pass K, Russell M, Hall D, Topf A, Brown D, Zelenika D, Bentham J et al. Circ Cardiovasc Genetics. 2013; 4: 347-353.
2013 Early percutaneous valve failure within bioprosthetic tricuspid tissue valve replacements. Bentham JR, Qureshi S, Eicken A, Ballard G, Gibbs J & Thomson J. Catheterizartion and cardiovascular interventions. 2013; 82: 428-435.
2013 Effect of Interventional Stent Treatment of Native and Recurrent Coarctation of Aorta on Blood Pressure. Bentham JR, English K, Ballard G, Thomson JD. Am J Cardiol. 2013; 111: 713-716.
2013 Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot. Cordell HJ, Töpf A, Mamasoula C, Postma AV, Bentham J et al. Hum Mol Genet. 2013; 22: 1473-1481.
2012 Functional significance of SRJ domain mutations in CITED2. Bentham J, Chen C-M et al. Plos One. 2012;7(10):e46256.
2012 Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. Somedi R, Wilson IJ, Bentham JR et al. Am J Hum Genet. 2012; 91: 489-501
2012 Effect of Transcatheter Closure of Baffle Leaks Following Senning or Mustard Atrial Redirection Surgery on Oxygen Saturations and Polycythaemia. Bentham JR, English K, Hares D, Gibbs J & Thomson J. American Journal of Cardiology. 2012; 110: 1046-1050.
2012 Early clinical experience with a modified Amplatzer Ductal Occluder for transcatheter arterial duct occlusion in infants and small children. Kenny D, Morgan G, Bentham J, Wilson N, Martin R, Tometzki A, Oslizlok P & Walsh K. Catheterization and cardiovascular interventions. In press.
2012 Transcatheter closure of persistent ductus arteriosus in adults. Bentham J, Thomson J & Gibbs J. Journal of interventional cardiology. 2012; 25: 501-504.
2012 Clinical management of Aortic Coarctation. Bentham J & Wilson N. Book Chapter in A comprehensive approach to Congenital Heart Disease. Editors I Vijayalakshmi, P Rao & R Chugh. Jaypee press, India.
2012 Stenting across head and neck vessels using covered stents for persisting aortic arch obstruction. Bentham J, Oswal N, Yates R. Cardiology in the Young. 2012; 22: 610-614.
2012 A common variant in the PTPN2 gene contributes to the risk of Tetralogy of Fallot. Goodship JA, Hall D, Topf A, Mamasoula C, Griffin H, Rahman TJ, Glen E, Tan H, Palomino Doza J, Relton CL, Bentham J et al. Circ Cardiovasc Genetics 2012; 5: 287-292.
2012 Interventional management of pulmonary vein stenosis. Bentham J, Wilson N. Book chapter. Editor Eeckhout E, Serruys PW, Vahanian A, Van Sambeek M, Wijns W. Percutaneous interventional cardiovascular medicine textbook, European Association of Percutaneous Cardiovascular Interventions. PCR publishing.
2012 Phenotype-Specific Effect of Chromosome 1q21.1 Rearrangements and GJA5 Duplications in 2437 Congenital Heart Disease Patients and 6760 Controls. Rachel Soemedi R, Topf A, Wilson I, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J et al. Human Molecular Genetics. 2012; 21: 1513-1520.
2011 Does technique of interventional closure of perimembranous ventricular septal defect reduce the incidence of heart block? Bentham J, Gujral A, Archer N, Adwani S & Wilson N. Cardiology in the Young. 2011; Feb 1: 1-10.
2011 Understanding congenital heart disease in the post-genomic era. Bentham J, Cosgrove C & Bhattacharya S. Horizons in Medicine 22.
2011 Emerging concepts in congenital heart disease. Bentham J, Bhattacharya S. Book chapter in Emerging concepts in cardiovascular development. Editor J. Pérez-Pomares & R Muñoz-Chápuli. Publisher Foxwell & Davies, UK. With editors.
2011 Catheter closure of the arterial duct in a preterm infant using echocardiography in the incubator. Bentham J, Meur S, Hudsmith L, Archer N & Wilson N. Catheterization and cardiovascular interventions. 2011; 77: 409-415.
2010 Endovascular stent placement is an acceptable alternative to reoperation in selected infants with residual or recurrent aortic arch obstruction Bentham J, Shettihalli N, Orchard E, Westaby S & Wilson N. Catheterization and cardiovascular interventions. 2010; 76: 852-859.
2010 Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects. Bentham J, Michell A, Lockstone H, Andrew D, Schneider J, Brown N & Bhattacharya S. Human Molecular Genetics. 2010; 19: 3394-3401.
2010 Mycotic aneurysm of the left ventricle. Bentham J, Wilson N & Westaby S. Pediatric Cardiology. 2010; 31: 747.
2010 Occlusion of anomalous systemic arterial supply in Scimitar syndrome using the new Amplatz vascular plug IV. Bentham J & Wilson N. Cardiology in the Young. 2010; 20: 349-350.
2010 Genetic & Molecular basis of Congenital Heart Disease. Bentham J, Bhattacharya S. Book chapter. Molecular mechanisms of cardiovascular disease. Editor R Kumar & P Elliott. Publisher Oxford University Press. ISBN 978-0-19-536895-6.
2009 Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. Griffin H, Hall D, Topf A, Eden J, Stuart A,Parsons J, Peart I, Deanfield J, O’Sullivan J, Bhattacharya S, Bentham J, Farrall M, Brook J, Burn J, Cordell H, Goodship J, Keavney B. Plos One. 2009; 4 (3): e4978.
2008 VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutations in the proprotein convertase Pcsk5. Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J et al. Genes & Development. 2008; 22: 1465-1477.
2008 Genetic Mechanisms in Congenital Heart Disease. Bentham J, Bhattacharya S. Annals of New York Academy of Science 2008; 1123:10-19.
2005 Some chronic obstructive pulmonary disease will originate in neonatal intensive care units. Bentham JR, Shaw NJ. Pediatric Respiratory Reviews 2005; 6: 29-32.
2005 Blood pressure in the neonate. Weindling AM, Bentham JR. Acta Paediatrica 2005; 94: 138-140.
2004 Cerebral Infarct and Meningitis secondary to Lemierre’s Syndrome. Bentham JR, Pollard A, Milford C, Anslow P, Pike M. Pediatric Neurology 2004; 30: 281-283.
2004 The internet – friend or foe? Bentham J and Todd P BMJ 2004; 328: 133.
2004 Confusing Coarctation. Bentham J and Todd P. Arch Dis Child 2004. 89: 7.
1999 Students conducting consultations in general practice and the acceptability to patients. Bentham JR, Burke J, Clark J, Svoboda C, Vallance G, Yeow M. Medical Education 1999; 33:686-687